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Cannabigerol or CBG molecular structural chemical formula against colorful science backdrop.

生物科学硕士aster's Student 研究 Could Lead to Improvements in Liver 疾病的结果

UNC's top-notch research facilities attracted Raznin 祝你好运。 Biological Sciences M.S. -论文集中课程. She was eager to learn lab techniques and research methodologies and was especially keen on 韩玉燕副教授 liver inflammation 以及疾病研究.

The 北科罗拉多大学’s top-notch research facilities attracted Raznin 祝你好运。 生物科学硕士.S. -论文集中课程. 乔利 was eager to learn laboratory techniques and 研究方法. 她特别热衷于 韩玉燕副教授 liver inflammation 以及疾病研究.

Han has been her mentor throughout her time at UNC. 随着她今年即将毕业, 乔利 is researching how cannabigerol (CBG) might mitigate liver disease toxicity. CBG is a cannabinoid, a non-psychoactive compound derived from the cannabis plant. She became interested 在 healing power of drugs at the University of Dhaka in her home country of Bangladesh, where she earned a bachelor's degree in Pharmacy and a master's degree in Clinical Pharmacy and Pharmacology.

“I'm always interested in looking at the therapeutic potential of any drug molecule and finding something that might be helpful for recovery from any disease,” 乔利 said.

That interest led to her investigation of CBG’s therapeutic potential in ameliorating liver inflammation, or scarring, in people with non-alcoholic steatohepatitis (NASH), a condition in which the liver builds up excessive fat deposits. 在临床前 animal study, 乔利 uses female 老鼠 to differentiate drug efficacy between genders.

UNC’s molecular genetics and research foundation classes helped prepare her for the 项目. In those courses, she learned about reviewing the literature, building the sample size and analyzing the statistics. While she conducted research, she also seized opportunities to enhance her credibility with在 field through writing 项目s 还有演讲活动.

Last December, 乔利 was listed as one of the authors of “Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor” 在 journal 营养物质 还有韩和其他人. In addition to writing about CBG research, 乔利 will present details of her research on female 老鼠 at UNC’s fall 2023 Biological Sciences Seminar.

Raznin乔利
Raznin乔利

“It is really meaningful for me to participate 在 seminar because I want to be a researcher, and public speaking is a skill I need to develop. 这个机会给予 me a chance to speak in front of a group of people to build up my confidence,” said 乔利.

The busy international student also works as a teaching assistant 在 生物科学学院College of Natural and 健康 Sciences. As the microbiology laboratory class instructor, she trains undergraduate students 在实验室技术中.

Han has overseen her work as a graduate student, helped her troubleshoot her thesis 项目 and allowed her the flexibility to work around her schedule. 她说乔利 has been a dedicated student who hasn’t let her fear of live 老鼠 prevent her from participating 在 animal study; instead, she has compensated by handling euthanized 老鼠. She recalled a night when, until almost midnight, she and 乔利 ran flow cytometry. This technology rapidly analyzes single cells or particles suspended in a buffered salt-based solution as they flow past lasers. 她说乔利 never complained about 迟到的时间.

“I teach her the basics, and then she continues to sharpen her skills. 几次之后 of semesters, our dynamic evolved to a kind of equally contributing input and output 我们之间,”韩说. “Raznin has made the obstacles — her fear of live 老鼠 and having a mother tongue that isn’t English — her motivation to stand out. 她长大了 so much in a short time, 在 lab, as a TA and as a highly motivated student.”

Han said 乔利's animal study on CBG is essential because much of the existing research has used only male 老鼠, making her research directly applicable to the female population NASH患者.

Next, 乔利 hopes to enroll in a doctoral program.

——布伦达·吉伦著

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